Publish Date: 
Mon, 05/07/2018 - 21:15

Initiating therapy: information on blood typing

Interference with indirect antiglobulin test (indirect Coombs test)

DARZALEX binds to CD38, which is found at low levels on red blood cells
(RBCs), and may result in a false positive indirect Coombs test.1

  • DARZALEX-mediated positive indirect Coombs test may persist for up to 6 months after the last DARZALEX infusion.
  • If a patient’s history of receiving DARZALEX is not clearly communicated to the blood bank, delays in the release of blood products for transfusion may occur.
  • If an emergency transfusion is required, non-crossmatched, ABO/RhD-compatible RBCs can be given, per local blood bank practices.

To ensure patients receive a timely transfusion:

Type and screen patients prior to starting DARZALEX. In the event of a planned transfusion, notify blood transfusion centres of this interference with indirect antiglobulin tests. If an emergency transfusion is required, non-cross-matched ABO/RhD-compatible RBCs can be given per local blood bank practices.1

1. DARZALEX® Product Information.